BIOS 5265 - Proteins as Biological Machines

The survey of principles of protein sequence, structure, and biological function. The course will review fundamental aspects of proteins, including amino acid sequence, structure, biological function, and biophysical properties such as solubility, folding, stability, molecular recognition and self-assembly, enzyme catalysis and evolution of protein function with respect to amino acid sequence and structure. Individual case studies of model proteins that have biomedical relevance or applications in diagnostic assays, biopharmaceuticals and nanotechnology, will be presented. The use of molecular graphics and bioinformatics software for visualization and analysis of protein sequence and structure will be emphasized.

Note: This course is approved for the capstone requirement for the Biology and Biomedical Sciences majors. Open to upper-level undergraduate and graduate students. Offered in fall or spring, possibly alternate years.

Credits: 3 hours